About 15% of patients with non-valvular atrial fibrillation might require percutaneous coronary interventions (PCIs) with stent placement to treat obstructive coronary artery disease. Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (aspirin) and P2Y12 antagonist is recommended after PCI. Patients requiring DAPT also require treatment with oral anticoagulation for atrial fibrillation. We conducted a meta-analysis to identify the antithrombotic regimen associated with the lowest rate of bleeding and thromboembolic events in non-valvular atrial fibrillation after PCI.

We searched PubMed, Embase, Scopus and Cochrane databases to identify randomized trials that investigated the use of dual antiplatelet therapy and vitamin K antagonist and/or Non-vitamin K antagonist oral anticoagulants (NOAC) (triple antithrombotic therapy (TAT)) against single antiplatelet agent and NOAC (dual antithrombotic therapy (DAT)) in the setting of coronary artery disease (CAD) requiring PCI and non-valvular atrial fibrill noted on analysis of NOAC specific DAT vs VKA based TAT.

The combination of an antiplatelet and NOACs (dual therapy) is associated with less risk of major bleeding and intracranial hemorrhage, with no significant difference in ischemic events (stroke myocardial infarction or stent thrombosis).

The combination of an antiplatelet and NOACs (dual therapy) is associated with less risk of major bleeding and intracranial hemorrhage, with no significant difference in ischemic events (stroke myocardial infarction or stent thrombosis).

Depression affects many children and adolescents, leading to poor academic performance, impaired psychosocial functioning, and an increased frequency of suicidal behavior. Depression has also been notably associated with trauma and distress tolerance. Our study sought to understand the relationships of these variables across age and sex categories in youth and adolescents.

The current study examined data from a total of 324 participants between the ages of 7 and 17 years-old who were a part of a larger study. Data related to age, sex, depression, trauma, and distress tolerance were examined.

A multiple regression revealed a significant interaction between age and sex on depression severity. Further, trauma and age by sex categories significantly predicted depression score, as well as distress tolerance predicting depression score. Lastly, a regression analysis, including trauma, distress tolerance, and age by sex categories were significant predictors of depression.

The results are limited by the cross-sectional design.

Clinicians should consider age by sex effects when treating childhood depression. Future research should further the understanding of depression across age and sex groups, as well as among children with extensive trauma experiences. Future research should also seek to further understand the implications of distress tolerance therapy on childhood depression.

Clinicians should consider age by sex effects when treating childhood depression. Future research should further the understanding of depression across age and sex groups, as well as among children with extensive trauma experiences. learn more Future research should also seek to further understand the implications of distress tolerance therapy on childhood depression.One of the most pervasive forms of regret, often connected to alcohol use, is sexual regret. Lifetime rates of regretted sexual experiences (RSE) for college students is between 29%-71.9%, with 31.8% endorsing past year RSE and 31.7% stating alcohol negatively influenced decision making. While past research has focused on psychological symptoms following sexual assault, psychological effects and subsequent outcomes of RSE remains under-studied. Whether a history of sexual regret is associated with mental health symptoms, alcohol use, and protective behavioral strategy (PBS) use in the past month was analyzed. Participants (n = 1,394; 57.68% females, 26.96% racial/ethnic minority) reported on internalizing symptoms (anxiety, depression, trauma symptoms, and suicidal ideation) and externalizing and protective behaviors (problematic alcohol use and PBS). It was hypothesized that those with a history of RSE would report heightened current psychological symptoms compared to those without a history of RSE, regardless of when the RSE occurred. Of the n = 1,394 participants, 39.96% reported sexual regret and 26.11% endorsed a history of sexual victimization. Results indicate that among participants with an RSE, past month symptoms of anxiety, depression, trauma, and suicidal ideation were heightened. A similar pattern emerged for problematic alcohol use, as those with a history of RSE engaged in more problematic alcohol use in the past month. For PBS, those with a history of RSE engaged in fewer PBS than those without. Understanding these factors may provide novel insight for mental health prevention efforts and intervention targets for individuals who experience sexual regret.

The general aim of the study was to examine the relative effectiveness and mediators of change in standardized mindfulness and compassion interventions.

A sample of 431 participants enrolled in a Mindfulness-Based Stress Reduction program (MBSR=277) and a Compassion Cultivation Training (CCT=154). The assessment before and after the program included a set of outcomes and mediators measures. A three-step data analysis plan was followed ANCOVAs, Reliable Change Index, and mediations (simple and multiple).

Both interventions yielded increased mindfulness, decentering, body awareness, and self-compassion. Yet, present-moment awareness improvements (i.e., decentering, and body awareness) were significantly larger in the MBSR than in CCT, whereas socio-emotional changes (i.e., common humanity and empathic concern) were larger in the CCT than in MBSR. The magnitude of effect sizes ranged from medium to large. Furthermore, both mindfulness and compassion interventions yielded similar changes in psychological distress (i.e., stress, anxiety, and depression), maladaptive cognitive processes (i.e., rumination and thought suppression), and well-being. The mediation models showed that although the MBSR program seemingly relies on changes in present-moment awareness mechanisms (i.e., decentering and body awareness) to reduce psychological distress and to improve well-being, the CCT program seemingly achieves the same positive outcomes through changes in socio-emotional mechanisms (i.e., common-humanity and empathy concern).

Due to our naturalistic design in real-world community setting, it was infeasible to randomly assign participants to conditions.

Our results suggest that mindfulness and compassion programs operate through different pathways to reduce psychological distress and to promote well-being.

Our results suggest that mindfulness and compassion programs operate through different pathways to reduce psychological distress and to promote well-being.