CONCLUSION Hypertension therapy by candesartan is more cost-effective than candesartan-amlodipine therapy with a price addition of IDR 580,993. Copyright © 2019 Faridah Baroroh, Andriana Sari, Noviana Masruroh.BACKGROUND Corncob is one of crude medication which containing phenolic compounds you can use as an energetic ingredient for sunscreen preparations. In this study, extracts of dried corn-cob made into a gel formula utilizing SRC (Semi Refined Carrageenan) and glucomannan as a gelling agent. AIM This study is designed to determine the perfect focus of SRC (Semi Refined Carrageenan) and glucomannan towards the real stability of this serum. TECHNIQUES Gel converted to four remedies with a ratio of just one 4 additionally the concentration of each and every formula ended up being 1%, 1.5%, 2%, 2.5%. Each formula ended up being evaluated for 6 days of storage that includes organoleptic test, homogeneity, pH, viscosity, dispersive power, freeze-thaw test and centrifugation. OUTCOMES The results revealed the fourth formula didn’t replace the organoleptic test and homogeneity test. Within the test split of this freeze-thaw technique, the 4th formula had been steady, within the centrifugation test formula 1 and 2 was been separation. pH and viscosity results acquired from statistics with a two-way ANOVA revealed significant variations in each formula. CONCLUSION Through the outcomes of this study concluded that the formula 3 with a concentration of 2% ended up being the suitable concentration as a gelling agent. Copyright © 2019 Kori Yati, Yudi Srifiana, Asri Indah Lestari.BACKGROUND Pregelatinizing is prepared to change framework of starch by heating a particular heat. Increasing of temperature triggers the starch to absorb water and enlarge quickly to be able to obtain a bigger particle dimensions. Bigger particle dimensions will improve flowability and compressibility regarding the granules. Pregelatinized taro starch can be used as diluent pills with damp granulation technique. AIM The objective analysis would be to figure out the consequence of increasing pregelatinized taro starch heat as diluent on compressibility and comprimability granule of thiamine hidrochloride compression. TECHNIQUES Pregelatinized taro starch is manufactured by warming the suspension system of starch at 50°C, 60°C and 70°C for 10 minutes and then dried. Pregelatinized taro starch is used as a filler of Thiamine Hidrocloride tablets which produced by wet granulation method. Test wereperformed for each formula such as for example quality tests of granules and pills real properties and assay. RESULT Granule compressibility analysis results reveal that the formula 1, 2, and 3 competent with compressibility price is 7.9941 correspondingly; 6.9929; and 5.9950%. From the results of the one-way ANOVA evaluation associated with the compressibility received sig. 0,000 significantly less than 0.05, then there is a significant difference between formula one utilizing the various other formulas. SUMMARY It shows the difference in temperature affect the compressibility pregelatinized taro starch. The higher the heat of pregelatinized taro starch, creates tablets with reduced compressibility. Copyright © 2019 Pramulani Mulya Lestari, Ari Widayanti, Hani Afifah.BACKGROUND Jackfruit Seeds (Artocarpus heterophyllus L.) are plants which can be considered able to decrease blood sugar. AIM the goal of this research would be to prove the game of jackfruit seeds in lowering blood glucose levels in gestational diabetic rats caused by streptozotocin and in silico study digital screening through molecular docking to discover the compounds in jackfruit seeds having interacting with each other with sulfonylurea receptors. PRACTICES The animals used in this study were Sprague Dawley strain pregnant feminine rats that have been split into six groups, namely the standard control group, unfavorable control, good control, different dose groups (100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW). After the rat ended up being expecting, the rats were induced first with streptozotocin so the rats had hyperglycemia. Blood glucose levels had been calculated in the 14th time after treatment. The information gotten were statistically tested by one-way ANOVA test accompanied by the HSD Tukey test. Digital screening was done making use of PLANTS 1.2 computer software. RESULTS the outcome showed that all sets of ethanol plant 70% of jackfruit seeds could decrease blood sugar levels. The greatest reduction in blood sugar amounts took place at dosage 3 with a dose of 400 mg/kg BW that has been 61.73%, similar to good eaat signals control glibenclamide. The outcomes of virtual testing with molecular docking revealed that betacarotene epoxide compounds have actually much better affinity than glibenclamide as a comparative element. SUMMARY it could be concluded that jackfruit seeds beta-carotene epoxide gets the prospective to cut back glucose levels by inducing insulin release. Copyright © 2019 Dwitiyanti Dwitiyanti, Rizky Arcinthya Rachmania, Kriana Efendi, Riri Septiani, Pahlevi Jihadudin.AIM The aim of this research was to determine cytotoxic activity of BornUSU we or Boronhafagama we (1,5-bis(4-hydroxyphenyl)-3-oxa-1,5-diaza-2,4-diboropentane-2,4-diol) as a boron derivate substances which are boron neutron captured theraphy (BNCT) candidates. METHODS The T47D cells were treated by BornUSU I, and Tamoxifen as a positive control. The in vitro study had been using MTT technique because of the incubation period for 24h and 48h. All information were determined utilizing viability of cells equation for showing each IC50 value. RESULTS The IC50 value of BornUSU I and Tamoxifen had been 72.61 ± 0.82 µM and 10.62 ± 0.06 µM for 24 h incubation duration, and for the 48 h incubation duration were 44.63 ± 0.23 µM and 7.79 ± 0.05 µM. The 48 h incubation period outcomes showed the best IC50 value. SUMMARY the outcomes reveal that BornUSU I offer efficient as anticancer, specifically for cancer of the breast therapy. Copyright © 2019 Nadiya Anandita Nasution, Urip Harahap, Ginda Haro, Hari Purnomo, Denny Satria.BACKGROUND Fast Orally Dissolving movie planning may be used for patients with issues in consuming solid dose forms, such as for example psychologically sick, elderly, geriatric and customers who’re reducing liquid intake or sickness.