0001). read more Study group patients incurred significantly higher 90-day episode-of-care costs ($15,124.55 vs. $14,610.01, p  less then  0.0001). Additionally, Paget’s disease patients were found to have higher incidences and odds of medical/surgical (25.93 vs. 13.58%; OR 1.64, p  less then  0.0001) and implant-related complications (8.97 vs. 5.02%; OR 1.71, p  less then  0.0001). Specifically, Paget’s disease patients were more likely to have periprosthetic fractures, mechanical loosening, and revision TKAs (p  less then  0.0001). This study demonstrated that Paget’s disease was associated with longer in-hospital LOS, increased costs, and higher rates of complications. The study can be utilized by physicians to adequately educate patients with Paget’s disease concerning potential complications following their primary TKA.

Diabetes mellitus (DM) is a major and increasing public health problem that may be underdiagnosed and undertreated among persons living with HIV (PLWH).

To describe the diagnosis, treatment and follow-up of DM among PLWH.

This study was performed inside a monocentric cohort of 1494 PLWH. DM was defined as having a FG ≥126 mg/dL twice or a HbA1c ≥6.5%, or a history of diabetes, or receiving antidiabetic treatment. The first visit mentioning a diagnosis of DM was considered as the baseline visit. Chi-Square or Fisher exact test were used to examine the association between categorical variables and DM, Wilcoxon or Student t-test were used for continuous variables.

156 PLWH with DM were included. Compared to non-diabetic participants, they were more likely to be native of Sub Saharan Africa (31.6% vs. 22.4%, p = 0.027) and older (54.6 vs. 49.9 years, p<0.001), to have a higher BMI (> 25 for 46.1% vs. 35.3%, p = 0.020) and a poorer control of HIV (HIV RNA<50 copies/mL 80.1% vs. 89.5%, p<0.001). The diagnosis of DM was missed in 37.8% of PLWH, and 47.2% of PLWH treated for DM did not reach a HbA1c<7%. PLWH with DM were more frequently on antihypertensive and/or lipid-lowering medications 94.2% had a LDL-cholesterol <70 mg/dL and 60.9% had a blood pressure <140/90 mmHg.

In a setting of HIV-control, HIV care providers should focus on metabolic issues. The management of DM and associated risk factors is mandatory to prevent cardiovascular disease in PLWH.

In a setting of HIV-control, HIV care providers should focus on metabolic issues. The management of DM and associated risk factors is mandatory to prevent cardiovascular disease in PLWH.

Cultural background, language, and literacy are factors that may affect access, health care utilization, and cancer screening behaviors.

This study aimed to characterize health literacy among Spanish-preferring Hispanic/Latino individuals ages 50-75 and examine associations between sociodemographic characteristics, health beliefs, and health literacy.

Participants self-identified as Hispanic/Latino, preferring health information in Spanish, were ages 50-75, at average risk for colorectal cancer, not up to date with colorectal cancer (CRC) screening, and enrolled in a CRC screening education intervention trial. Sociodemographic characteristics, health beliefs, and health literacy (i.e., difficulty understanding written health information and confidence completing health forms) were assessed at baseline. Descriptive and logistic regression analyses were performed.

Fifty-three percent of participants reported either sometimes having difficulty or always having difficulty with written health information, and 25% reported always asking for help or being not so confident in completing health forms. Univariate predictors of adequate health literacy for written health information were lower cancer worry and lower religious beliefs. Higher educational attainment predicted confidence in completing health forms.

Findings highlight the need for interventions that address health beliefs and health literacy among Hispanic/Latino patients who have low confidence in completing written forms and difficulty understanding written information and reinforce the use of plain language and salient design features when developing patient education materials.

Findings highlight the need for interventions that address health beliefs and health literacy among Hispanic/Latino patients who have low confidence in completing written forms and difficulty understanding written information and reinforce the use of plain language and salient design features when developing patient education materials.

To describe longitudinal multimodal imaging findings of non-exudative choroidal neovascularization (CNV) in CTRP5 late-onset retinal degeneration (CTRP5-LORD).

Four patients with CTRP5-positive LORD underwent repeated ophthalmoscopic examination and multimodal imaging. All four patients (two siblings and their cousins, from a pedigree described previously) had the heterozygous S163R mutation.

All four patients demonstrated large subretinal lesions in the mid-peripheral retina of both eyes. The lesions were characterized by confluent hypercyanescence with hypocyanescent borders on indocyanine green angiography, faintly visible branching vascular networks with absent/minimal leakage on fluorescein angiography, type 1 neovascularization on OCT angiography, and absent retinal fluid, consistent with non-exudative CNV. The neovascular membranes enlarged substantially over time and the birth of new membranes was observed, but all lesions remained non-/minimally exudative. Without treatment, all involved retinal areas remained free of atrophy and subretinal fibrosis.

We report the existence of massive advancing non-exudative type 1 CNV in CTRP5-LORD. These findings have implications for age-related macular degeneration (AMD). They provide a monogenic model system for studying the mechanisms underlying the distinct events of CNV development, enlargement, progression to exudation, and atrophy in AMD. They suggest that choroidal hypoperfusion precedes neovascularization and that non-exudative neovascularization may protect against atrophy.

We report the existence of massive advancing non-exudative type 1 CNV in CTRP5-LORD. These findings have implications for age-related macular degeneration (AMD). They provide a monogenic model system for studying the mechanisms underlying the distinct events of CNV development, enlargement, progression to exudation, and atrophy in AMD. They suggest that choroidal hypoperfusion precedes neovascularization and that non-exudative neovascularization may protect against atrophy.