We conclude that bilinguals are cross-linguistically influenced by L1 phonotactic constraints during L2 processing when metalinguistic demands are higher, suggesting that L2 input may be mapped onto L1 sub-lexical representations during perception. MK-0859 These results extend previous research on language co-activation and speech perception by providing a more fine-grained understanding of task demands and elucidating when and where cross-linguistic phonotactic access is present during bilingual comprehension.In heart failure, cardiac fibrosis is the result of an adverse remodeling process. Collagen is continuously synthesized in the myocardium in an ongoing attempt of the heart to repair itself. The resulting collagen depositions act counterproductively, causing diastolic dysfunction and disturbing electrical conduction. Efforts to treat cardiac fibrosis specifically have not been successful and the molecular etiology is only partially understood. The differentiation of quiescent cardiac fibroblasts to extracellular matrix-depositing myofibroblasts is a hallmark of cardiac fibrosis and a key aspect of the adverse remodeling process. This conversion is induced by a complex interplay of biochemical signals and mechanical stimuli. Tissue-engineered 3D models to study cardiac fibroblast behavior in vitro indicate that cyclic strain can activate a myofibroblast phenotype. This raises the question how fibroblast quiescence is maintained in the healthy myocardium, despite continuous stimulation of ultimately profibrotic mechanotransductive pathways. In this review, we will discuss the convergence of biochemical and mechanical differentiation signals of myofibroblasts, and hypothesize how these affect this paradoxical quiescence. Impact statement Mechanotransduction pathways of cardiac fibroblasts seem to ultimately be profibrotic in nature, but in healthy human myocardium, cardiac fibroblasts remain quiescent, despite continuous mechanical stimulation. We propose three hypotheses that could explain this paradoxical state of affairs. Furthermore, we provide suggestions for future research, which should lead to a better understanding of fibroblast quiescence and activation, and ultimately to new strategies for the prevention and treatment of cardiac fibrosis and heart failure.The pathogenic human enterovirus EV-A71 has raised serious public health concerns. A hallmark of EV-A71 infection is the distortion of host transcriptomes in favour of viral replication. While high-throughput approaches have been exploited to dissect these gene dysregulations, they do not fully capture molecular perturbations at the single-cell level and in a physiologically relevant context. In this study, we applied a single-cell RNA sequencing approach on infected differentiated enterocyte cells (C2BBe1), which model the gastrointestinal epithelium targeted initially by EV-A71. Our single-cell analysis of EV-A71-infected culture provided several lines of illuminating observations 1) This systems approach demonstrated extensive cell-to-cell variation in a single culture upon viral infection and delineated transcriptomic differences between the EV-A71-infected and bystander cells. 2) By analysing expression profiles of known EV-A71 receptors and entry facilitation factors, we found that ANXA2 was closely correlated in expression with the viral RNA in the infected population, supporting its role in EV-A71 entry in the enteric cells. 3) We further catalogued dysregulated lncRNAs elicited by EV-A71 infection and demonstrated the functional implication of lncRNA CYTOR in promoting EV-A71 replication. Viewed together, our single-cell transcriptomic analysis illustrated at the single-cell resolution the heterogeneity of host susceptibility to EV-A71 and revealed the involvement of lncRNAs in host antiviral response.Vertical stiffness has been highlighted as a potential determinant of performance and may be estimated across a range of different performance tasks. The aim of the current study was to investigate the relationship between vertical stiffness determined during 9 different hopping tests and performance of vertical jumps. Twenty healthy, active males performed vertical hopping tests with three different strategies (self-selected, maximal, and controlled) and three different limb configurations (bilateral, unilateral preferred, and unilateral non-preferred), resulting in nine different variations, during which vertical stiffness was determined. In addition, participants performed squat jump (SQJ) and countermovement jump (CMJ) during which jump height, CMJ stiffness, and eccentric utilization ratio (EUR) were determined. Vertical stiffness in bilateral and unilateral preferred tasks performed with a self-selected and maximal, but not controlled, strategy was associated with stiffness in the CMJ (r = 0.61-0.64; p  less then  0.05). However, stiffness obtained during unilateral preferred and non-preferred hopping with self-selected strategy was negatively associated with performance in SQJ and CMJ tasks (r = -0.50 to -0.57; p  less then  0.05). These findings suggest that high levels of vertical stiffness may be disadvantageous to static vertical jumping performance. In addition, unilateral hopping with a self-selected strategy may be the most appropriate task variation if seeking to determine relationships with vertical jumping performance. HighlightsStiffness obtained during unilateral hopping with a preferred strategy was negatively associated with vertical jumping performancesStiffness obtained during hopping with preferred and maximal strategies was associated with stiffness obtained during a countermovement jumpIn this population, hopping stiffness may therefore be reflective of an individual’s countermovement jump strategyHigh levels of stiffness may be disadvantageous to static-start vertical jumping.ABSTRACTPrismatic adaptation (PA) with wedge prisms is a non-invasive technique used in the rehabilitation of patients suffering from spatial neglect. Unfortunately, as for many behavioural intervention techniques, it is nearly impossible to achieve adequate blinding using wedge prisms, and the potential benefit of PA in the rehabilitation of neglect remains controversial. In order to study an alternative to wedge prism, we examine whether virtual PA at different degrees of deviation may alleviate signs of neglect in a double-blind design. Fifteen neglect patients participated in three adaptation sessions, which differed by the degree of deviation (0°, 15°, or 30°). Performance in line bisection and item cancellation tasks was measured in virtual reality immediately before and after adaptation. Session allocation was concealed from patients and the examiner. Despite the presence of robust, dose-dependent effects of virtual PA on Open-Loop Pointing (OLP), no transfer to line bisection and item cancellation tests were observed.