K-ras codon 12 mutations are commonly occurring mutations in different forms of types of cancer and leads to resistance against anti-EGFR therapeutics. Hence, determination of mutations in k-ras gene is crucial for predicting a reaction to anti-EGFR therapies. This study aimed to judge the prevalence of k-ras gene mutations and CA125 tumor marker in patients with ovarian carcinoma in Tabriz city. Methods Genomic DNA ended up being extracted from 67 tissues pertained to women with ovarian carcinoma. Mutations in codon 12 and 13 of k-ras gene were analyzed by Nested PCR and RFLP techniques. Titer of CA125 tumor marker had been determined by ELISA. Results Among the list of 67 customers, 7 customers (10.4%) had mutation in k-ras codon 12 while none of them had mutation in k-ras codon 13. In line with the results, the regularity of varied genotypes were 89.55%, 10.44%, and 0%, for GG, GA, and AA alleles, correspondingly. The p-value for stage we and Grade I tumors were 0.022 and 0.04, respectively, showing a statistically significant correlation between codon 12 mutation and phase we and level I tumors. Furthermore, we found considerable correlations among CA125 tumefaction marker titers and histological class (p less then 0.000) and stage (p less then 0.000). The mean serum CA125 tumefaction marker levels in malignant carcinomas had been 499.84 U/ml. Conclusion The leads to this research indicated high prevalence of k-ras codon 12 mutations and large titer of CA125 tumor marker in customers with ovarian carcinoma into the research area.Background Delay in diagnosis and remedy for TB is a crucial element in TB control program which therefore distributing infection in the community. Sicnce Golestan province has the high risk with a high prices of tuberculosis in the united kingdom, consequently, the evaluation regarding the elements associated with therapy delay in this province for effective interventions and correct planning is regarded as necessary. Practices 689 clients papers of TB instances in the health division of Golestan University of Medical Sciences in 2016 had been enrolled in this study. The response variable in this study was getting the delay or perhaps not (via determining the 34 day as cut-off part of the interval between your time of start of signs and symptoms and the time of treatment start-up). The information were analyzed using SPSS 24 computer software and last considerable amount for multivariate logistic regression design had been considered 0.05. Outcomes Median (mean) treatment wait ended up being calculated 49(77.75) days. In the current research 60.4% of clients had complete wait more than 34 times. In final design factors such as sort of PTB (OR=0.645), contact record (clients who’d no experience of TB clients (OR=1.441)) and clients just who their contact history were unknown (OR=1.654)) had significant relationship with delay in starting therapy after 34 times of onset of symptoms of PTB patients in Golestan (p less then 0.05). Conclusion It should beam focus on increasing the community’s knowing of the observable symptoms of tuberculosis and effective collaboration should be made amongst the Infectious Disease Control Center in addition to personal and community sectors.Background Candidiasis is one of the most common fungal infections in immunosuppressed customers. The problem is usually treated with neighborhood and systemic antifungal agents. Given the antifungal properties of propolis, it appears this all-natural resin product can be efficient in treating this illness. The purpose of the current in vitro research would be to compare the result of Iranian propolis with those of routine antifungal agents on Candida types separated through the oral candida lesions of patients with cancer, that has withstood chemotherapy, and a regular strain of Candida albicans. Practices A total of 23 samples were collected from the oral cavities of patients with colorectal cancer, that has withstood chemotherapy with 5-fu. The fungal types were determined in line with the results of tradition in C. albicans chromagar medium, development of the germ tube and formation of vesicles. The MIC of aqueous extract propolis (AEP) and ethanolic plant of propolis (EEP) and amphotericin B (AMP-B), fluconazole (FL) and nystatin (NYS) had been contrasted. Results a complete of 23 oral C. albicans examples had been separated. The MICs of FL and AMP- B were similar much less than those of EEP, AEP and NYS (P less then 0.001). In inclusion, the MIC of AEP was more than EEP (P less then 0.001). The MIC of AMP- B regarding the strains separated from the patients was more than compared to the standard strain (P=0.012). Conclusion The aqueous and ethanolic extracts of Iranian propolis exhibited antifungal activity, with a greater effect of the EEP when compared to AEP.Background The superiority of TG/HDL-C and LDL-C/HDL-C ratios in predicting CVD risk is a matter of debates. Thus, the objective of this research was to compare TG/HDL-C and LDL-C to HDL-C ratios in predicting the risk of CVD occasions. Methods In a population-based cross-sectional research, 567 representative participants aged 40 many years or older had been entered within the study in Babol, North of Iran. The demographic data, anthropometric actions, therefore the cardio metabolic threat factors had been measured. The in-patient threat of CVD occasions ended up being evaluated by ACC/AHA danger model. ROC evaluation had been applied to estimate the diagnostic precision while the optimal cut-off points of TG/HDL-C and LDL-C/HDL-C ratios. Outcomes The AUC of TG/HDL-C and LDL-C/HDL-C ratios were instead similar and both parameters substantially predicted CVD threat in guys comparably, and TG/HDL-C at ideal cutoff point of 3.6 produced 75% sensitiveness and 39% specificity. However,in women TG/HDL-C with AUC of 0.65( p=0.091) at ideal cutoff worth of TransmembraneTransporters 3.4 produced a sensitivity of 82% and specificity of 51%. The LDL-C/HDL-C ratio had no discriminative capability in predicting CVD threat in women.