Inhibition of CASC2 caused increased expression of miR-144. Furthermore, mechanistic investigations confirmed that activation of the miR-144/SOCS2 regulatory loop by overexpression of miR-144 reversed the in vitro effects of CASC2 on inhibiting cell apoptosis, inflammatory factor release, and fibrosis. In addition, simultaneous overexpression of…[Read more]

Mice generated after blastomere removal also had increased circulating leptin and leptin gene expression in adipose tissue, as well as increased ghrelin receptor gene expression in the hypothalamus, compared to control mice. The effects of blastomere biopsy on offspring phenotype were sexually dimorphic, with females not being affected. These…[Read more]

In the clayey soil, compaction caused a significant increase in soluble and exchangeable Pb, accompanied by a significant reduction in environmentally stable Pb (inner sphere adsorption on gibbsite and kaolinite). In addition, studies about Pb contents under compacted soil layers should be investigated, mainly in clayey soils with edible crops,…[Read more]

Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD).

The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women.

All relevant articles reporting pregnancy…[Read more]