For example, OTULIN interferes with endosome-to-plasma membrane trafficking and the OTULIN-related pseudo-DUB OTULINL (FAM105A) resides at the endoplasmic reticulum (ER). Here, we discuss how OTULIN contributes to cell fate control and highlight novel ubiquitin-dependent and -independent functions.Despite the emerging evidence on ferroptosis…[Read more]

Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk factor. We present real-life characteristics of patients with increased Lp(a) levels attending a University Lipid Clinic.

We retrospectively studied patients attending the University of Ioannina Hospital Lipid Clinic with Lp(a) levels ≥30mg/dL who were followed-up for a median o…[Read more]

bation parameters are compatible with success.

The relationship between the changes in extubation parameters through successive attempts is driven primarily by the value obtained immediately prior to re-extubation. These findings do not support waiting for an improvement in extubation parameters to extubate patients who failed a first attempt…[Read more]

Heart rates leveled off beyond 18°C at any CO2 level. Cardiac output continued to increase with high-CO2-warming, due to elevated cardiac stroke volumes. Consequently, temperature-dependent branchial hemolymph flow remained unaffected by CO2. Instead, a suppressing effect of CO2 on ventilation was found beyond 16°C. These results indicate c…[Read more]

evant to other countries and donors seeking to optimise LLIN distribution.

The assignment of the intervention was not at the discretion of the investigators; therefore, this study did not require registration.

The assignment of the intervention was not at the discretion of the investigators; therefore, this study did not require…[Read more]

The risk of HE-related hospitalization over the follow-up was higher in patients with higher MELD score and worse Scan performance. Mortality was higher in those with higher MELD. Among patients without a history of overt HE, those with worse PHES had higher HE risk. Among patients with a history, those with higher MELD, better PHES and worse Scan…[Read more]