Peak-to-trough ratios in the repeated-dose study ranged from 1.3-1.4 with once-weekly dosing and 5.9-12.9 with once-monthly dosing. Following a single dose of efpeglenatide 14-100 μg/kg, FPG and PPG levels were decreased at week 1 and remained below baseline levels for ≥3 weeks post-dosing. Repeated doses of efpeglenatide led to significant redu…[Read more]