0 and 61.8 mg/L in plasma after 6 and 10 days of treatment, respectively. Temocillin concentrations were found to be above the determined MIC of 6 mg/L. From the measured concentrations, we can postulate that 100%fT>MIC was achieved in urine and at least equal to 40% in plasma.

Temocillin dosing adjustment performed in the present repor…[Read more]

A new type A botulinum toxin (BoNT/A) preparation, JTM201 (NCBI chromosomal DNA ID CP046450), has been developed, which comprises 900-kDa complexed toxin purified from Clostridium botulinum (strain NCTC13319), but its safety and efficacy have not yet been evaluated. The purpose of this study was to evaluate the long-term efficacy and safety of…[Read more]