However, restoring sirtuin 1 by RESV administration significantly blocked the BPA-induced decrease in NBS1 and subsequently attenuated the BPA-induced impairment of DNA repair and apoptosis, as indicated by phosphorylated H2AX expression and staining and PARP expression. Moreover, RESV administration significantly ameliorated BPA-aggravated…[Read more]

Down syndrome (DS) is the most frequent chromosomal disorder. It is caused by the triplication of human chromosome 21, leading to increased dosage of a variety of genes including APP (Amyloid Precursor Protein). Mainly for this reason, individuals with DS are at high risk to develop Alzheimer’s disease (AD). Extensive literature identified various…[Read more]