suggesting a more limited role for bacterial methionine metabolism genes in host lifespan effects. In a parallel set of experiments we created a distinct bacterial strain that expressed lifespan-extending methionine metabolism genes and show that this strain can extend fly lifespan. Therefore, this work identifies specific bacterial genes that…[Read more]

These results emphasise the key role of the mutual antagonism between the Nodal and BMP2/4 pathways in driving early dorsal-ventral patterning of the sea urchin embryo.Drosophila sensory organ precursors divide asymmetrically to generate pIIa/pIIb cells, the identity of which relies on activation of Notch at cytokinesis. Although Notch is present…[Read more]

Oral mucositis is a complication of cancer therapy, causing severe pain that affects oral functioning, nutrition, and quality of life, as well as therapy nonadherence or dose-limiting toxicity. Anecdotal experience has suggested that methylene blue (MB) oral rinse may be an effective and safe treatment of this oral pain.

To evaluate the…[Read more]