Opioid abuse is a major health problem. The objective of the present study was to evaluate the potentially disruptive side effects and therapeutic potential of a novel antagonist (D24M) of the mu-/delta-opioid receptor (MOR/DOR) heterodimer in male rats. Administration of high doses of D24M (1 & 10 nmol) into the lateral ventricle did not disrupt…[Read more]

A novel noninterpenetrated tetranuclear cobalt(II)-based metal-organic framework, (NH4)2·[Co4(μ3-OH)2(ina)2(pip)3]·4EtOH·H2O (simplified as NbU-10·S), constructed by mix linkers was synthesized by a hydrothermal method. Interestingly, the presence of a hydrophobic benzene ring in the organic linker makes NbU-10·S exhibit high stability in high…[Read more]

The conventional “top-down”, “bottom-up” and “combination” approaches of generating drug nanocrystals produce a “nanosuspension” (NS). It requires significant downstream processing for drying the liquid by suitable means followed by its granulation to develop an oral solid dosage form (OSD). In this paper, we used a novel, spray drying-based…[Read more]