We report the first disclosure of IRAK3 degraders in the scientific literature. Taking advantage of an opportune byproduct obtained during our efforts to identify IRAK4 inhibitors, we identified ready-to-use, selective IRAK3 ligands in our compound collection with the required properties for conversion into proteolysis-targeting chimera (PROTAC)…[Read more]

29, 95% CI 0.16, 0.50) and ethnicity (0.40, 95% CI 0.23, 0.69).

These findings suggest a variety of socio-demographic and economic factors as well as media exposure are associated with women’s use of ANC. Policymakers should implement appropriate measures to address the existing variations and gaps in ANC services utilization among…[Read more]