A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound 2 in particular exhibited excellent in vitro potency with an EC50 value of 5 nM. This new scaffold was then further refined…[Read more]

23 ± 176.53 ng/ml; TNF-α 57.53 ± 3.87 pg/ml), while markedly been suppressed in the treatment group (AS-L IgE 1100.25 ± 135.32 ng/ml; TNF-α 38.47 ± 3.26 pg/ml; AS-H IgE 459.46 ± 74.75 ng/ml; TNF-α 24.38 ± 3.85 pg/ml). Among Th17 cell-related factors, DNCB treatment increased mRNA expression of IL-6, IL-17, IL-23, STAT3, and ROR-γt, but reduced T…[Read more]